THE SMART TRICK OF PKRRATING THAT NOBODY IS DISCUSSING

3B). R526 from your loop in between αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the primary chain carbonyl of R413. The idea in the activation phase is stabilized by a hydrogen bond involving Y454 and E480 from αF. fr